Editas Medicine to Present Pipeline and Platform Data Demonstrating Progress Towards Developing Transformative Gene Editing Medicines at the American Society of Gene and Cell Therapy Annual Meeting
Key
- Preclinical data on EDIT-202 demonstrating maintained expression levels of CD16 and mbIL15, prolonged persistence in the absence of exogeneous cytokines and significantly enhanced anti-tumor efficacy in an in vivo solid tumor model.
- Safety data from the BRILLIANCE trial of EDIT-101 demonstrating a favorable immunogenic profile.
- Preclinical data from non-human primate studies of EDIT-103, in development for the treatment of rhodopsin-associated autosomal dominant retinitis pigmentosa (RHO-adRP), demonstrating nearly 100% gene editing knockout of endogenous RHO gene and more than 30% replacement protein levels.
- Data demonstrating SLEEK (SeLection by Essential-gene Exon Knock-in) gene editing is an optimal strategy for achieving robust multi-transgene knock-in for the next generation of cell therapy medicines.
“Editas Medicine is making strong progress towards the clinic with our preclinical pipeline and in our efforts to develop transformative medicines for people living with serious diseases, including ocular diseases, hemoglobinopathies, and cancer,” said
The complete list of
Oral Presentations:
Title: Exploratory Immuno-Safety Profile of EDIT-101, a First-in-Human In
Session Date and Time:
Presentation Time:
Session title: Gene and Cell Therapy Trials in Progress
Title: SLEEK: A Method for Highly Efficient Knock-in and Expression of Transgene Cargos for Next-generation Cell-based Medicines
Session Date and Time:
Presentation Time:
Session title: New Gene Editing Technologies and Applications
Title: A Mutation-Independent CRISPR/Cas9-Based ʻKnockout and Replaceʼ Strategy to Treat Rhodopsin-Associated Autosomal Dominant Retinitis Pigmentosa
Session Date and Time:
Presentation Time:
Session title: Ophthalmic and Auditory Diseases
Poster Presentation:
Title: EDIT-202, A Multiplexed CRISPR-Cas12a Gene-Edited iPSC-Derived NK Cell Therapy has Prolonged Persistence, Promotes High Cytotoxicity, and Enhances In
Session Date and Time:
Session Title: Cancer - Targeted Gene and Cell Therapy II
About
As a leading genome editing company,
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Contacts: MediaCristi Barnett (617) 401-0113 cristi.barnett@editasmed.com InvestorsRon Moldaver (617) 401-9052 ir@editasmed.com
Source: Editas Medicine, Inc.
