<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:019fb808-2414-76dc-95f9-bd04b34812d7,g:2696aaff-cbaf-4362-9882-61f2d4278a93-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.editasmedicine.com/role/DocumentandEntityInformation" xlink:type="simple" xlink:href="edit-20260803.xsd#DocumentandEntityInformation"/>
  <link:presentationLink xlink:role="http://www.editasmedicine.com/role/DocumentandEntityInformation" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_dei_CoverAbstract_019fb808-2414-7911-bb0b-0f1b55a1f3b2" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_CoverAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_019fb808-2414-7f17-addf-ee538b59d3a3" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentType"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019fb808-2414-7911-bb0b-0f1b55a1f3b2" xlink:to="loc_dei_DocumentType_019fb808-2414-7f17-addf-ee538b59d3a3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_019fb808-2414-720c-9ab7-bda050bd8141" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentPeriodEndDate"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019fb808-2414-7911-bb0b-0f1b55a1f3b2" xlink:to="loc_dei_DocumentPeriodEndDate_019fb808-2414-720c-9ab7-bda050bd8141" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_019fb808-2414-7ad6-aee2-c3caeb0a0f30" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityFileNumber"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019fb808-2414-7911-bb0b-0f1b55a1f3b2" xlink:to="loc_dei_EntityFileNumber_019fb808-2414-7ad6-aee2-c3caeb0a0f30" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_019fb808-2414-786f-b2a4-211453f7772c" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityRegistrantName"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019fb808-2414-7911-bb0b-0f1b55a1f3b2" xlink:to="loc_dei_EntityRegistrantName_019fb808-2414-786f-b2a4-211453f7772c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_019fb808-2414-78f9-b4e5-db61bc2daf74" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019fb808-2414-7911-bb0b-0f1b55a1f3b2" xlink:to="loc_dei_EntityIncorporationStateCountryCode_019fb808-2414-78f9-b4e5-db61bc2daf74" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_019fb808-2414-76e3-acfe-ecae49bf1d84" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019fb808-2414-7911-bb0b-0f1b55a1f3b2" xlink:to="loc_dei_EntityTaxIdentificationNumber_019fb808-2414-76e3-acfe-ecae49bf1d84" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_019fb808-2414-7531-831e-b1830d16f19e" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressAddressLine1"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019fb808-2414-7911-bb0b-0f1b55a1f3b2" xlink:to="loc_dei_EntityAddressAddressLine1_019fb808-2414-7531-831e-b1830d16f19e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_019fb808-2414-7bc2-9bbb-589c2c6466da" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressCityOrTown"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019fb808-2414-7911-bb0b-0f1b55a1f3b2" xlink:to="loc_dei_EntityAddressCityOrTown_019fb808-2414-7bc2-9bbb-589c2c6466da" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_019fb808-2414-7bc6-aaca-ef9f20e3cce9" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressStateOrProvince"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019fb808-2414-7911-bb0b-0f1b55a1f3b2" xlink:to="loc_dei_EntityAddressStateOrProvince_019fb808-2414-7bc6-aaca-ef9f20e3cce9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_019fb808-2414-7960-b201-5a49d1065ae0" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityAddressPostalZipCode"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019fb808-2414-7911-bb0b-0f1b55a1f3b2" xlink:to="loc_dei_EntityAddressPostalZipCode_019fb808-2414-7960-b201-5a49d1065ae0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_019fb808-2414-7a2c-9e40-d1145b8907c2" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_CityAreaCode"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019fb808-2414-7911-bb0b-0f1b55a1f3b2" xlink:to="loc_dei_CityAreaCode_019fb808-2414-7a2c-9e40-d1145b8907c2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_019fb808-2414-74bd-b32b-f893b11e06ab" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_LocalPhoneNumber"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019fb808-2414-7911-bb0b-0f1b55a1f3b2" xlink:to="loc_dei_LocalPhoneNumber_019fb808-2414-74bd-b32b-f893b11e06ab" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_WrittenCommunications_019fb808-2414-7ea7-8008-2056c174c1bf" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_WrittenCommunications"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019fb808-2414-7911-bb0b-0f1b55a1f3b2" xlink:to="loc_dei_WrittenCommunications_019fb808-2414-7ea7-8008-2056c174c1bf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SolicitingMaterial_019fb808-2414-763a-9df3-2563164ba03d" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_SolicitingMaterial"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019fb808-2414-7911-bb0b-0f1b55a1f3b2" xlink:to="loc_dei_SolicitingMaterial_019fb808-2414-763a-9df3-2563164ba03d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementTenderOffer_019fb808-2414-7815-9cf6-fffbc57df9b7" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_PreCommencementTenderOffer"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019fb808-2414-7911-bb0b-0f1b55a1f3b2" xlink:to="loc_dei_PreCommencementTenderOffer_019fb808-2414-7815-9cf6-fffbc57df9b7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementIssuerTenderOffer_019fb808-2414-79e6-a486-3681ba0d9033" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_PreCommencementIssuerTenderOffer"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019fb808-2414-7911-bb0b-0f1b55a1f3b2" xlink:to="loc_dei_PreCommencementIssuerTenderOffer_019fb808-2414-79e6-a486-3681ba0d9033" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_019fb808-2414-73de-ae83-ef64755f2593" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_Security12bTitle"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019fb808-2414-7911-bb0b-0f1b55a1f3b2" xlink:to="loc_dei_Security12bTitle_019fb808-2414-73de-ae83-ef64755f2593" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_019fb808-2414-7843-b148-295cdef25841" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_TradingSymbol"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019fb808-2414-7911-bb0b-0f1b55a1f3b2" xlink:to="loc_dei_TradingSymbol_019fb808-2414-7843-b148-295cdef25841" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_019fb808-2414-7327-aa5a-d8b15ca94e61" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_SecurityExchangeName"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019fb808-2414-7911-bb0b-0f1b55a1f3b2" xlink:to="loc_dei_SecurityExchangeName_019fb808-2414-7327-aa5a-d8b15ca94e61" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_019fb808-2414-781f-ab2a-dfc783ba21b4" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019fb808-2414-7911-bb0b-0f1b55a1f3b2" xlink:to="loc_dei_EntityEmergingGrowthCompany_019fb808-2414-781f-ab2a-dfc783ba21b4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_019fb808-2414-71c9-8ce8-76e111f18d6f" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_EntityCentralIndexKey"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019fb808-2414-7911-bb0b-0f1b55a1f3b2" xlink:to="loc_dei_EntityCentralIndexKey_019fb808-2414-71c9-8ce8-76e111f18d6f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_019fb808-2414-751e-9e02-a39b623b6bc6" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_AmendmentFlag"/>
    <link:presentationArc order="22" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019fb808-2414-7911-bb0b-0f1b55a1f3b2" xlink:to="loc_dei_AmendmentFlag_019fb808-2414-751e-9e02-a39b623b6bc6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentInformationTable_019fb808-2414-7a2d-bde2-29a355f9471d" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentInformationTable"/>
    <link:presentationArc order="23" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_019fb808-2414-7911-bb0b-0f1b55a1f3b2" xlink:to="loc_dei_DocumentInformationTable_019fb808-2414-7a2d-bde2-29a355f9471d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentInformationLineItems_019fb808-2414-71c8-8669-98d2c7c4cca8" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentInformationLineItems"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationTable_019fb808-2414-7a2d-bde2-29a355f9471d" xlink:to="loc_dei_DocumentInformationLineItems_019fb808-2414-71c8-8669-98d2c7c4cca8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_019fb808-2414-74b2-bffc-675a1e191595" xlink:href="https://xbrl.sec.gov/dei/2025/dei-2025.xsd#dei_DocumentPeriodEndDate"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_019fb808-2414-71c8-8669-98d2c7c4cca8" xlink:to="loc_dei_DocumentPeriodEndDate_019fb808-2414-74b2-bffc-675a1e191595" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
</link:linkbase>
