0000001 - Document - Cover link:presentationLink link:calculationLink link:definitionLink 0000002 - Document - Audit Information link:presentationLink link:calculationLink link:definitionLink 9952151 - Statement - Consolidated Balance Sheets link:presentationLink link:calculationLink link:definitionLink 9952152 - Statement - Consolidated Balance Sheets (Parenthetical) link:presentationLink link:calculationLink link:definitionLink 9952153 - Statement - Consolidated Statements of Operations link:presentationLink link:calculationLink link:definitionLink 9952154 - Statement - Consolidated Statements of Comprehensive Loss link:presentationLink link:calculationLink link:definitionLink 9952155 - Statement - Consolidated Statements of Stockholders' Equity link:presentationLink link:calculationLink link:definitionLink 9952156 - Statement - Consolidated Statements of Cash Flows link:presentationLink link:calculationLink link:definitionLink 9952157 - Statement - Consolidated Statements of Cash Flows (Parenthetical) link:presentationLink link:calculationLink link:definitionLink 9952158 - Disclosure - Nature of Business link:presentationLink link:calculationLink link:definitionLink 9952159 - Disclosure - Summary of Significant Accounting Policies link:presentationLink link:calculationLink link:definitionLink 9952160 - Disclosure - Cash Equivalents and Marketable Securities link:presentationLink link:calculationLink link:definitionLink 9952161 - Disclosure - Fair Value Measurements link:presentationLink link:calculationLink link:definitionLink 9952162 - Disclosure - Property and Equipment, Net link:presentationLink link:calculationLink link:definitionLink 9952163 - Disclosure - Accrued Expenses link:presentationLink link:calculationLink link:definitionLink 9952164 - Disclosure - Leases link:presentationLink link:calculationLink link:definitionLink 9952165 - Disclosure - Commitments and Contingencies link:presentationLink link:calculationLink link:definitionLink 9952166 - Disclosure - Collaboration Agreements link:presentationLink link:calculationLink link:definitionLink 9952167 - Disclosure - Preferred Stock link:presentationLink link:calculationLink link:definitionLink 9952168 - Disclosure - Common Stock link:presentationLink link:calculationLink link:definitionLink 9952169 - Disclosure - Stock-Based Compensation link:presentationLink link:calculationLink link:definitionLink 9952170 - Disclosure - 401(k) Savings Plan link:presentationLink link:calculationLink link:definitionLink 9952171 - Disclosure - Income Taxes link:presentationLink link:calculationLink link:definitionLink 9952172 - Disclosure - Net Loss per Share link:presentationLink link:calculationLink link:definitionLink 9952173 - Disclosure - Debt link:presentationLink link:calculationLink link:definitionLink 9952174 - Disclosure - Restructuring and Impairment Charges link:presentationLink link:calculationLink link:definitionLink 9952175 - Disclosure - Segments link:presentationLink link:calculationLink link:definitionLink 9952176 - Disclosure - Subsequent Events link:presentationLink link:calculationLink link:definitionLink 9955511 - Disclosure - Summary of Significant Accounting Policies (Policies) link:presentationLink link:calculationLink link:definitionLink 9955512 - Disclosure - Summary of Significant Accounting Policies (Tables) link:presentationLink link:calculationLink link:definitionLink 9955513 - Disclosure - Cash Equivalents and Marketable Securities (Tables) link:presentationLink link:calculationLink link:definitionLink 9955514 - Disclosure - Fair Value Measurements (Tables) link:presentationLink link:calculationLink link:definitionLink 9955515 - Disclosure - Property and Equipment, Net (Tables) link:presentationLink link:calculationLink link:definitionLink 9955516 - Disclosure - Accrued Expenses (Tables) link:presentationLink link:calculationLink link:definitionLink 9955517 - Disclosure - Leases (Tables) link:presentationLink link:calculationLink link:definitionLink 9955518 - Disclosure - Collaboration Agreements (Tables) link:presentationLink link:calculationLink link:definitionLink 9955519 - Disclosure - Common Stock (Tables) link:presentationLink link:calculationLink link:definitionLink 9955520 - Disclosure - Stock-Based Compensation (Tables) link:presentationLink link:calculationLink link:definitionLink 9955521 - Disclosure - Income Taxes (Tables) link:presentationLink link:calculationLink link:definitionLink 9955522 - Disclosure - Net Loss per Share (Tables) link:presentationLink link:calculationLink link:definitionLink 9955523 - Disclosure - Debt (Tables) link:presentationLink link:calculationLink link:definitionLink 9955524 - Disclosure - Restructuring and Impairment Charges (Tables) link:presentationLink link:calculationLink link:definitionLink 9955525 - Disclosure - Segments (Tables) link:presentationLink link:calculationLink link:definitionLink 9955526 - Disclosure - Nature of Business (Details) link:presentationLink link:calculationLink link:definitionLink 9955527 - Disclosure - Summary of Significant Accounting Policies - Cash, Cash Equivalents, and Restricted Cash (Details) link:presentationLink link:calculationLink link:definitionLink 9955528 - Disclosure - Summary of Significant Accounting Policies - Accounts Receivable (Details) link:presentationLink link:calculationLink link:definitionLink 9955529 - Disclosure - Summary of Significant Accounting Policies - Property and Equipment and Impairment of Long-lived Assets (Details) link:presentationLink link:calculationLink link:definitionLink 9955530 - Disclosure - Summary of Significant Accounting Policies - Liability for Sale of Future Revenues (Details) link:presentationLink link:calculationLink link:definitionLink 9955531 - Disclosure - Summary of Significant Accounting Policies - Success Payments, Research Funding Payments and Notes Payables (Details) link:presentationLink link:calculationLink link:definitionLink 9955532 - Disclosure - Cash Equivalents and Marketable Securities - Cash Equivalents and Marketable Securities (Details) link:presentationLink link:calculationLink link:definitionLink 9955533 - Disclosure - Fair Value Measurements (Details) link:presentationLink link:calculationLink link:definitionLink 9955534 - Disclosure - Property and Equipment, Net (Details) link:presentationLink link:calculationLink link:definitionLink 9955535 - Disclosure - Accrued Expenses (Details) link:presentationLink link:calculationLink link:definitionLink 9955536 - Disclosure - Leases - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955537 - Disclosure - Leases - Right of Use Asset and Lease Liability (Details) link:presentationLink link:calculationLink link:definitionLink 9955538 - Disclosure - Leases - Maturities of Lease Liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 9955538 - Disclosure - Leases - Maturities of Lease Liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 9955539 - Disclosure - Commitments and Contingencies - Research Funding Payments (Details) link:presentationLink link:calculationLink link:definitionLink 9955540 - Disclosure - Commitments and Contingencies - Milestones (Details) link:presentationLink link:calculationLink link:definitionLink 9955541 - Disclosure - Commitments and Contingencies - Licensor Expense Reimbursements (Details) link:presentationLink link:calculationLink link:definitionLink 9955542 - Disclosure - Commitments and Contingencies - Royalties and Success Payments (Details) link:presentationLink link:calculationLink link:definitionLink 9955543 - Disclosure - Collaboration Agreements - Accounts Receivable and Contract Liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 9955544 - Disclosure - Collaboration Agreements - Change in Contract Assets and Contract Liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 9955545 - Disclosure - Collaboration Agreements - BMS Collaboration Agreement (Details) link:presentationLink link:calculationLink link:definitionLink 9955546 - Disclosure - Collaboration Agreements - Beam Therapeutics (Details) link:presentationLink link:calculationLink link:definitionLink 9955547 - Disclosure - Collaboration Agreements - Vertex Pharmaceuticals License Agreement (Details) link:presentationLink link:calculationLink link:definitionLink 9955548 - Disclosure - Preferred Stock (Details) link:presentationLink link:calculationLink link:definitionLink 9955549 - Disclosure - Common Stock - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955550 - Disclosure - Common Stock - Shares Reserved for Future Issuance (Details) link:presentationLink link:calculationLink link:definitionLink 9955551 - Disclosure - Stock-Based Compensation - Stock-Based Compensation Expense (Details) link:presentationLink link:calculationLink link:definitionLink 9955552 - Disclosure - Stock-Based Compensation - Restricted Stock and Stock Options (Details) link:presentationLink link:calculationLink link:definitionLink 9955553 - Disclosure - Stock-Based Compensation - Assumptions (Details) link:presentationLink link:calculationLink link:definitionLink 9955554 - Disclosure - 401(K) Savings Plan (Details) link:presentationLink link:calculationLink link:definitionLink 9955555 - Disclosure - Income Taxes - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955556 - Disclosure - Income Taxes - Effective Income Tax Rate (Details) link:presentationLink link:calculationLink link:definitionLink 9955557 - Disclosure - Income Taxes - Components of Deferred Tax Assets and Liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 9955558 - Disclosure - Income Taxes - Unrecognized Tax Benefits (Details) link:presentationLink link:calculationLink link:definitionLink 9955559 - Disclosure - Net Loss per Share (Details) link:presentationLink link:calculationLink link:definitionLink 9955560 - Disclosure - Debt - Schedule of Debt (Details) link:presentationLink link:calculationLink link:definitionLink 9955561 - Disclosure - Restructuring and Impairment Charges - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955562 - Disclosure - Restructuring and Impairment Charges - Schedule of Restructuring and Related Costs (Details) link:presentationLink link:calculationLink link:definitionLink 9955563 - Disclosure - Restructuring and Impairment Charges - Schedule of Employee Termination Benefits (Details) link:presentationLink link:calculationLink link:definitionLink 9955564 - Disclosure - Restructuring and Impairment Charges - Schedule of Contract Termination Costs (Details) link:presentationLink link:calculationLink link:definitionLink 9955565 - Disclosure - Restructuring and Impairment Charges - Schedule of Accelerated Depreciation and Rent Expense (Details) link:presentationLink link:calculationLink link:definitionLink 9955566 - Disclosure - Segments - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955567 - Disclosure - Segments - Schedule of Segment Reporting Information, by Segment (Details) link:presentationLink link:calculationLink link:definitionLink