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Your Vote Counts! EDITAS MEDICINE, INC.2022 Annual Meeting Vote by June 8, 2022 11:59 PM ETEDITAS MEDICINE, INC. 11 HURLEY STREET CAMBRIDGE, MA 02141D78745-P69101You invested in EDITAS MEDICINE, INC. and it’s time to vote! You have the right to vote on proposals being presented at the Annual Meeting. This is an important notice regarding the availability of proxy material for the stockholder meeting to be held on June 9, 2022. Get informed before you vote View the Notice and Proxy Statement, 2021 Annual Report and form of proxy online OR you can receive a free paper or email copy of the material(s) by requesting prior to May 26, 2022. If you would like to request a copy of the material(s) for this and/or future stockholder meetings, you may (1) visit www.ProxyVote.com, (2) call 1-800-579-1639 or (3) send an email to sendmaterial@proxyvote.com. If sending an email, please include your control number (indicated below) in the subject line. Unless requested, you will not otherwise receive a paper or email copy.For complete information and to vote, visit www.ProxyVote.com Control #Smartphone users Point your camera here and vote without entering a control numberVirtually at:Vote Virtually at the Meeting* June 9, 2022 8:30 AM EDTwww.virtualshareholdermeeting.com/EDIT2022*Please check the meeting materials for any special requirements for meeting attendance.V1.1







Vote at www.ProxyVote.comTHIS IS NOT A VOTABLE BALLOT This is an overview of the proposals being presented at the upcoming stockholder meeting. Please follow the instructions on the reverse side to access the more complete proxy materials, which contain important information, and to vote these important matters. You are encouraged to access and review the complete proxy materials before voting.Voting Items 1. Election of three Class III Directors, each to serve until the 2025 Annual Meeting of Stockholders. Nominees: 01) Jessica Hopfield, Ph.D. 02) Emma Reeve 03) David T. Scadden, M.D. 2. To approve, on an advisory basis, the compensation paid to the Company’s named executive officers. 3. To ratify the appointment of Ernst & Young LLP as the Company’s independent registered public accounting firm for the fiscal year ending December 31, 2022. NOTE: Such other business as may properly come before the meeting or any adjournment thereof.Board RecommendsFor For ForPrefer to receive an email instead? While voting on www.ProxyVote.com, be sure to click “Sign up for E-delivery”.D78746-P69101