UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549
FORM
CURRENT REPORT
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If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐
Item 2.02 Results of Operations and Financial Condition.
On February 25, 2021, Editas Medicine, Inc. (the “Company”) issued a press release announcing financial results for the fiscal quarter and year ended December 31, 2020 and other business highlights. A copy of the press release is being furnished as Exhibit 99.1 to this Current Report on Form 8-K.
The information contained in Item 2.02 in this Current Report on Form 8-K (including Exhibit 99.1) shall not be deemed “Filed” for purposes of Section 18 of the Securities Exchange Act of 1934 (the “Exchange Act”) or otherwise subject to the liabilities of that section, nor shall it be deemed incorporated by reference in any filing under the Securities Act of 1933 or the Exchange Act, except as expressly set forth by specific reference in such a filing.
Item 9.01 Financial Statements and Exhibits.
(d) Exhibits
Exhibit |
| Description |
99.1 |
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104 | Cover Page Interactive Data File (embedded within the Inline XBRL document) |
* This exhibit shall be deemed to be furnished and not filed.
SIGNATURES
Pursuant to the requirements of the Securities Exchange Act of 1934, as amended, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.
| EDITAS MEDICINE, INC. | ||||
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Date: | February 25, 2021 | By: | /s/ Michelle Robertson | ||
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| Michelle Robertson | ||
Exhibit 99.1
Editas Medicine Announces Fourth Quarter and Full Year 2020 Results and Update
Strengthened Leadership by Appointing James (Jim) C. Mullen as President and Chief Executive Officer, and Lisa A. Michaels, M.D., as Chief Medical Officer
Appointed Meeta Chatterjee, Ph.D., to Board of Directors
Initiated dosing of adult mid-dose cohort of BRILLIANCE trial of EDIT-101 for LCA10
Initiated Phase 1/2 RUBY trial for EDIT-301 for sickle cell disease
Ended 2020 with strong cash position of $512 million, and raised additional $250 million in early 2021
CAMBRIDGE, Mass., Feb. 25, 2021 – Editas Medicine, Inc. (Nasdaq: EDIT), a leading genome editing company, today reported business highlights and financial results for the fourth quarter and full year 2020.
“Editas has a once-in-a-generation technology enabling us to develop transformational medicines. Entering 2021, we are advancing the landmark Brilliance trial, the first ever in vivo gene editing program and we look forward to reporting clinical data later this year”, said James C. Mullen, Chairman, President, and Chief Executive Officer, Editas Medicine. “Editas is also advancing our ex vivo gene edited medicines and we plan to begin enrollment in the Phase 1/2 RUBY clinical trial for the treatment of sickle cell disease. We also expect to make significant progress in our edited iNK cell therapy program for oncological treatments.”
Recent Achievements and Outlook
In Vivo Gene Edited Medicines
● EDIT-101 for Leber Congenital Amaurosis 10 (LCA10)
Dosed first patient in the adult mid-dose cohort of the BRILLIANCE trial
Editas Medicine has dosed the first patient of the second cohort, the adult mid-dose, with EDIT-101. Initial clinical data is expected in 2021.
● Retinitis Pigmentosa Type 4
On track for development candidate by end of 2021
Editas Medicine is on-track to declare a development candidate for the treatment of Retinitis Pigmentosa Type 4 (adRP4) by the end of 2021. The Company plans to present preclinical data at a scientific meeting later this year.
Ex Vivo Gene Edited Cell Medicines
● EDIT-301 for Sickle Cell Disease
Initiation of Phase 1/2 RUBY trial
The U.S. Food and Drug Administration (FDA) has approved the start of the Phase 1/2 RUBY study for sickle cell disease, and the Company can begin enrolling patients. Initial clinical sites for RUBY trial are expected to be approved by the second quarter of 2021, and the Company expects to dose the first patient before year-end. Editas Medicine is prepared for the manufacturing of clinical production of EDIT-301 through internal capabilities and manufacturing partners.
On track for Investigational New Drug (IND) filing for the treatment of beta-thalassemia by end of 2021
The Company is on track to file an IND application to the FDA for EDIT-301 for the treatment of beta-thalassemia by the end of 2021.
● Edited iPSC NK (iNK) Cell Medicines to Treat Solid Tumors
Proprietary CRISPR/Cas12a editing of iPSCs enhances iNK tumor killing for potential off-the-shelf medicine
Preclinical data presented at the 62nd Annual Meeting and Exposition of the American Society of Hematology (ASH) highlighted the Company’s CRISPR/Cas12a induced pluripotent stem cell (iPSC) editing platform. Editas Medicine demonstrated that knockout of CISH and TGFβR2 with the proprietary CRISPR/Cas12a editing platform enhanced iNK cell tumor killing. Specifically, iNK cells containing the double knockout clones, were more effective than control iNK cells in killing tumor cells in a spheroid model. These data, supported by leveraged learnings from Editas Medicine’s discontinued healthy donor-derived NK cell program, continue to guide the Company’s clinical oncology strategy.
Corporate
● Leadership
On February 15, 2021, James (Jim) Mullen was appointed as President and Chief Executive Officer of Editas Medicine, in addition to his existing role as Chairman of the Board. Jim is a recognized biotech leader with more than 40 years of experience building leading biotechnology and pharmaceutical organizations on a global scale. As CEO and President at Biogen, one of the world’s largest biotechnology companies, Mr. Mullen oversaw the development and launch of many successful medicines. More recently, Mr. Mullen served as CEO of Patheon NV, a leading global provider of pharmaceutical development and manufacturing services, until its acquisition by Thermo Fisher Scientific in 2017.
In November, the Company announced the appointment of Lisa A. Michaels, M.D., as Chief Medical Officer. Dr. Michaels has more than 25 years of experience in clinical research and drug development in both industry and academia. Dr. Michaels joined Editas Medicine from Bayer Pharmaceuticals where she spent more than 10 years in drug development, leading teams from early research and drug discovery through regulatory approval, commercial launch, and life cycle management. Most recently, she served as head of Bayer’s Rare Diseases, Cell & Gene Therapy therapeutic area.
In December, the Company appointed Meeta Chatterjee, Ph.D., to its Board of Directors. Dr. Chatterjee is an accomplished biopharmaceutical executive with more than 30 years of
broad strategic and operational experience in research and development, mergers and acquisition evaluation, in-licensing, and externalization activities.
● Manufacturing
Editas Medicine continues to advance internal and external manufacturing capabilities for the Company’s portfolio of in vivo gene edited medicines and ex vivo gene edited cell medicines. The transfer of manufacturing materials from AbbVie to Editas Medicines was completed and the Company can progress the ocular medicines pipeline following reacquiring the rights from AbbVie. The Company is also expanding internal capability of manufacturing GMP guide RNA’s for future programs at the Boulder, Colorado facility.
● Balance Sheet
The Company expects that its existing cash, cash equivalents and marketable securities of $512 million at December 31, 2020, will enable it to fund its operating expenses and capital expenditures into 2023. This cash position does not include the $250 million of net proceeds from the public offering that occurred in early 2021.
Fourth Quarter and Full Year 2020 Financial Results
Cash, cash equivalents, and marketable securities at December 31, 2020, were $512 million, compared to $541 million at September 30, 2020, and $457 million at December 31, 2019.
For the three months ended December 31, 2020, net loss was $62.5 million, or $1.00 per share, compared to $37.8 million, or $0.74 per share, for the same period in 2019.
● Collaboration and other research and development revenues decreased by $0.9 million, to $11.4 million for the three months ended December 31, 2020 from $12.3 million for three months ended December 31, 2019. This decrease was primarily attributable to the recognition of revenue under the Allergan collaboration in the three months ended December 31, 2019 for which there was no similar revenue in the three months ended December 31, 2020 as a result of the termination of our strategic alliance with Allergan.
● Research and development expenses increased by $26.7 million, to $61.5 million for the three months ended December 31, 2020 from $34.8 million for the three months ended December 31, 2019. The $26.7 million increase was primarily attributable to a recognition of $27.5 million in success payment expense related to a success payment triggering event in the three months ended December 31, 2020, and an increase in expenses related to the clinical and manufacturing development of EDIT-101, EDIT-301 and our other programs, partially offset by a decrease in sublicensing expense.
● General and administrative expenses decreased by $1.1 million to $15.8 million for the three months ended December 31, 2020, from $16.9 million for the same period in 2019. The $1.1 million decrease was primarily attributable to a decrease in expense related to stock-based compensation due to a modification that occurred in 2019 for which there was no similar activity in 2020 and decreased performance bonus expense due to employee turnover in the fourth quarter of 2020.
For the full year 2020, net loss attributable to common stockholders was $116.0 million, or $1.98 per share, compared to $133.7 million, or $2.68 per share, for the same period in 2019.
● Collaboration and other research and development revenues were $90.7 million for 2020, compared to $20.5 million for 2019. The $70.2 million increase was primarily attributable to a $57.1 million increase in the revenue recognized as a result of the termination of our strategic alliance with Allergan as well as increases in revenue recognized pursuant to our other collaboration and out-licensing agreements.
● Research and development expenses were $158.0 million for 2020, compared to $96.9 million for 2019. The $61.1 million increase was primarily attributable to increased process and platform development expenses driven by increased manufacturing and clinical related costs, including costs to progress EDIT-101 and EDIT-301, increased expenses related to the triggering of a $27.5 million success payment in 2020 and increased employee-related costs, partially offset by a decrease in sublicense and license fees. Remaining success payments will only be payable upon a combination of product candidate and market capitalization triggers.
● General and administrative expenses were $67.6 million for 2020, compared to $64.6 million for 2019. The $3.0 million increase was primarily attributable to increased employee-related costs and facility expenses due to an increased workforce, partially offset by decreased stock-based compensation expense.
Upcoming Events
Editas Medicine will participate in the following investor events:
● Cowen & Company 41st Annual Health Care Conference, March 1, Virtual
● Barclays Global Healthcare Conference, March 10, Virtual
Editas Medicine will participate in the following scientific and medical conferences:
● American Association of Cancer Research Annual Meeting, April 10-15, Virtual
● Association for Research in Vision and Ophthalmology Annual Meeting, May 1-7, Virtual
Conference Call
The Editas Medicine management team will host a conference call and webcast today at 8:00 a.m. ET to provide and discuss a corporate update and financial results for the fourth quarter and full year 2020. To access the call, please dial (844) 348-3801 (domestic) or (213) 358-0955 (international) and provide the passcode 7172199. A live webcast of the call will be available on the Investors & Media section of the Editas Medicine website at www.editasmedicine.com and a replay will be available approximately two hours after its completion.
About Editas Medicine
As a leading genome editing company, Editas Medicine is focused on translating the power and potential of the CRISPR/Cas9 and CRISPR/Cas12a (also known as Cpf1) genome editing systems into a robust pipeline of treatments for people living with serious diseases around the world. Editas Medicine aims to discover, develop, manufacture, and commercialize transformative, durable, precision genomic medicines for a broad class of diseases. For the latest information and scientific presentations, please visit www.editasmedicine.com.
About EDIT-101
EDIT-101 is a CRISPR-based experimental medicine under investigation for the treatment of Leber congenital amaurosis 10 (LCA10). EDIT-101 is administered via a subretinal injection to reach and deliver the gene editing machinery directly to photoreceptor cells.
About BRILLIANCE
The BRILLIANCE Phase 1/2 clinical trial of EDIT-101 for the treatment of Leber congenital amaurosis 10 (LCA10) is designed to assess the safety, tolerability, and efficacy of EDIT-101 in up to 18 patients with this disorder. Clinical trial sites are enrolling up to five cohorts testing up to three dose levels in this open label, multi-center study. Both adult and pediatric patients (3 – 17 years old) with a range of baseline visual acuity assessments are eligible for enrollment. Patients receive a single administration of EDIT-101 via subretinal injection in one eye. Additional details are available on www.clinicaltrials.gov (NCT#03872479).
About EDIT-301
EDIT-301 is an experimental, autologous cell therapy medicine under investigation for the treatment of sickle cell disease. EDIT-301 is comprised of sickle patient CD34+ cells genetically modified using a highly specific and efficient CRISPR/Cas12a (also known as Cpf1) ribonucleoprotein (RNP) that targets the HBG1 and HBG2 promoters in the beta-globin locus where naturally occurring fetal hemoglobin (HbF) inducing mutations reside. Red blood cells derived from EDIT-301 CD34+ cells demonstrate a sustained increase in HbF production, which has the potential to provide a durable treatment benefit for people living with sickle cell disease.
About RUBY
The RUBY Trial is a single-arm, open-label, multi-center Phase 1/2 study designed to assess the safety and efficacy of EDIT-301 in patients with severe sickle cell disease. Enrolled patients will receive a single administration of EDIT-301.
Forward-Looking Statements
This press release contains forward-looking statements and information within the meaning of The Private Securities Litigation Reform Act of 1995. The words "anticipate," "believe," "continue," "could," "estimate," "expect," "intend," "may," "plan," "potential," "predict," "project," "target," "should," "would," and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Forward-looking statements in this press release include statements regarding the initiation, timing, progress and results of the Company’s preclinical and clinical studies and its research and development programs, including the initiation of the RUBY trial and filing an IND for EDIT-301 for the treatment of beta-thalassemia by the end of 2021, the timing for the Company’s receipt and presentation of data from its clinical trials and preclinical studies, including EDIT-101, and the timing or likelihood of regulatory filings and approvals. The Company may not actually achieve the plans, intentions, or expectations disclosed in these forward-looking statements, and you should not place undue reliance on these forward-looking statements. Actual results or events could differ materially from the plans, intentions and expectations disclosed in these forward-looking statements as a result of various factors, including: uncertainties inherent in the initiation and completion of preclinical studies and clinical trials and clinical development of the Company’s product candidates; availability and timing of results from preclinical studies and clinical trials; whether interim results from a clinical trial will be predictive of the final results of the trial or the results of future trials; expectations for regulatory approvals to conduct trials or to market products and availability of funding sufficient for the Company’s foreseeable and unforeseeable operating expenses and capital expenditure requirements. These and other risks are described in greater detail under the caption “Risk Factors” included in the Company’s most recent Quarterly Report on Form 10-Q, which is on file with the Securities and Exchange Commission, and in other filings that the Company may make with the Securities and Exchange Commission in the future. Any forward-looking
statements contained in this press release speak only as of the date hereof, and the Company expressly disclaims any obligation to update any forward-looking statements, whether because of new information, future events or otherwise.
EDITAS MEDICINE, INC.
Consolidated Statement of Operations
(amounts in thousands, except share and per share data)
(Unaudited)
| | Three Months Ended | | Twelve Months Ended | | ||||||||
| | December 31, | | December 31, | | ||||||||
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| 2020 |
| 2019 |
| 2020 |
| 2019 |
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Collaboration and other research and development revenues | | $ | 11,419 | | $ | 12,284 | | $ | 90,732 | | $ | 20,531 | |
Operating expenses: | | | | | | | | | | | | | |
Research and development | | | 61,505 | | | 34,789 | | | 157,996 | | | 96,898 | |
General and administrative | | | 15,788 | | | 16,918 | | | 67,576 | | | 64,555 | |
Total operating expenses | | | 77,293 | | | 51,707 | | | 225,572 | | | 161,453 | |
Operating loss | | | (65,874) | | | (39,423) | | | (134,840) | | | (140,922) | |
Other income, net: | | | | | | | | | | | | | |
Other income(expense), net | | | 2,853 | | | 8 | | | 16,259 | | | (137) | |
Interest income, net | | | 522 | | | 1,645 | | | 2,605 | | | 7,313 | |
Total other income, net | | | 3,375 | | | 1,653 | | | 18,864 | | | 7,176 | |
Net loss | | $ | (62,499) | | $ | (37,770) | | $ | (115,976) | | $ | (133,746) | |
Net loss per share attributable to common stockholders, basic and diluted | | $ | (1.00) | | $ | (0.74) | | $ | (1.98) | | $ | (2.68) | |
Weighted-average common shares outstanding, basic and diluted | | | 62,278,035 | | | 51,169,242 | | | 58,609,389 | | | 49,983,329 | |
EDITAS MEDICINE, INC.
Selected Consolidated Balance Sheet Items
(amounts in thousands)
(Unaudited)
| | December 31, | | December 31, | | ||
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| 2020 |
| 2019 |
| ||
Cash, cash equivalents, and marketable securities | | $ | 511,774 | | $ | 457,140 | |
Working capital | | | 358,894 | | | 403,881 | |
Total assets | | | 572,602 | | | 508,885 | |
Deferred revenue, net of current portion | | | 73,984 | | | 163,207 | |
Total stockholders' equity | | | 393,586 | | | 262,437 | |
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Contacts:
Media
Cristi Barnett
(617) 401-0113
cristi.barnett@editasmed.com
Investors
Editas Medicine Investor Relations
(617) 401-9052
ir@editasmed.com